Prof. Dr. Vladimir Trajkovski

srijeda, 16.05.2012.

Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3-6 years old

Jolanta Wasilewska1, Maciej Kaczmarski1, Anna Stasiak-Barmuta2, Jolanta Tobolczyk2, Ewa Kowalewska3
Arch Med Sci 2012; 8, 2: 324-331
DOI: 10.5114/aoms.2012.28561
Copyright © 2012 Termedia & Banach

A b s t r a c t
Introduction: Immune system dysfunction is considered to be one of many medical
disorders found in children with autism. The primary objective of the study
was to assess if blood tests reflecting humoral immunity (IgA, IgG, IgM, IgE) are
useful in identifying children with regressive autism. The secondary objective
was to evaluate a part of the cellular arm of immunity (CD4/CD25 Tregs,
CD4/CD23 cells) in those children.
Material and methods: Using a clinical case-control design, the systemic levels
of immunoglobulins and lymphocyte subpopulations analysed by flow cytometry
were compared in children aged 3-6 years old with a new diagnosis of regressive
autism (n = 24; mean age: 4.25 ±1.70 years; male 23/24) and in sex- and
age-matched healthy children (n = 24; aged 4.25 ±2.20 years; male 23/24).
Results: The humoral immunity profile, described by three binary variables,
IgA < 0.97 g/l, IgE > 36 IU/ml, and IgG > 6.3 g/l, with a sensitivity of 79% and
a specificity of 83% (p < 0.0001), was able to identify children with autism. The
highest risk of autism diagnosis was associated with IgA < 0.97g/l (OR – 23.0;
p < 0.001). A higher number of CD19/CD23 was found in children diagnosed with
autism than in the control group (36.82 ±6.72% vs. 18.20 ±3.95%; p < 0.02). No
correlation between the number of CD23-positive cells and serum IgE levels was
observed.
Conclusions: A subtle shift of serum immunoglobulins consisting of low-normal
IgA and B cell activation expressed by an increase of CD23-positive cells may
characterize children with regressive autism aged 3-6 years old.

Naš citat referenca 20
20. Spiroski M, Trajkovski V, Trajkov D, et al. Family analysis of immunoglobulin classes and subclasses in children
with autistic disorder. Bosn J Basic Med Sci 2009; 9: 283-9.

- 09:49 - Komentari (0) - Isprintaj - #

ponedjeljak, 26.03.2012.

New issue of Journal of Special Education and Rehabilitation

Dear readers,

Today 26.03.2012 newest issue of JSER was released No. 1-2, Vol. 13, 2012.

This year the academic journal “Journal of Special Education and Rehabilitation” is celebrating its 15 year of existence among the home and world specialized journalism. It is not a long period, but long enough to be able to make some analysis. The publication began as an unpretentious local journal that analyzed the issues related to the practice of special education and rehabilitation and its allied sciences, for later to grow into well accredited international journal with 18 members in its Editorial Board, from which more than 60% are foreign experts and authors form around 20 European and World countries. In this occasion, I would like to thank the first Editor-in-Chief Prof. d-r Ljupcho Ajdinski, PhD, and his deputy editor, the speech therapist Velichko Andreevski, for their brave steps and thriving idea to incept this academic journal. Compliments also deserve the remaining members of the editorial office that in the past 15 years gave their effort in building this contemporary publication up to our readers’ standards. It is obvious that in the past four years the number of indexing and abstracting has increased and in the present it has reached up to 54 major world databases and esteemed libraries.
The road to achieving the factor of influencing is long, painful, and fulfilled with many challenges. However, our journal has to reach the “Mont Everest in the world of academic publishing”. With this issue 1-2 for 2012, the journal enters a phase of new evaluation done by the company Thomson Scientific, and our hope remains that in the next issue we will publish that strongly desired factor of influence. Hereby should be acknowledged that the rate of rejected articles has increased up to 40%, which directly increased the quality of the published ones. The authors have to realize that when two independent reviewers will write a negative review, then the editorial office is left with the only choice to respect this decision, fully aware that this will meet some dissatisfaction among the authors in question. As an illustration, I would like to remind that the SCI indexes less then 2% of the journals coming from the developing countries, and so far in Macedonia the editors of only two journals can enjoy such achievement. There is defeating data that only 10-15% of the articles are scientifically useful. Half of the articles never and by nobody are being cited, and half of the journals are standing untouched on the libraries’ bookshelves.
The readers of this issue can read interesting contents by authors from Austria, Bosnia and Herzegovina, Canada, Macedonia, Serbia and Croatia. Various topics from diverse areas are offered: the role of the family in the early intervention; the visual perception in children with plexus brachialis impairment; the occurrence of stuttering among the children with Down syndrome; hearing and visual impairment as a risk factor for depression; the subjective observation of the wellbeing of parents of special needs children; the development of the Quality of Life approach among persons with disability; and is established an analysis of the errors among the children with stigmatisam in the Bosnian-Croatian-Serbian language.
In the news and information section are being distributed five intriguing contents of held seminars and conferences, with the last one announcing the upcoming scientific symposium under the title “Inclusive education-condition and challenges”. It will be held in Strumica, Macedonia, in the period between 17th and 19th of May, 2012. After follows an abstract from a defended Master’s Thesis and the issue concludes as usual: bibliography, list of reviewers and index of authors.
Dear readers, I strongly advise us all to purchise Macedonian academic journals, because in that way we prolong the lifespan of the academic journalism, while getting educated in certain domains of our area of practice.

With great respect,
Editor-in-Chief
Prof. d-r Vladimir Trajkovski, MD, PhD

- 23:48 - Komentari (0) - Isprintaj - #

subota, 17.03.2012.

World Down Syndrome Day

Respected readers,
World Down Syndrome Day will be celebrated in Skopje and Strumica, Macedonian towns on 21st of March this year. I will give a lecture entitled: "Does the Down syndrome is enough understood in Macedonia?". I hope that there will be enough people and that media will cover this event. Thanks a lot to local Down syndrome NGO "Vera" for inviting me there.
Lecturer

- 23:58 - Komentari (0) - Isprintaj - #

nedjelja, 26.02.2012.

Zorica Kondža - A bog da znae

Dragi hrvtaski prijatelji,

Malo ko zna u Hrvatskoj da Zorica Kondža odlično pjeva na makedonskom. Evo vam dokaze. Ovo je otpjevano na Makfestu 1989 godine.

DJ Vac

- 18:29 - Komentari (0) - Isprintaj - #

utorak, 14.02.2012.

Massimo - Dodirni me slučajno

Dragi prijatelji,
U ovo teško vrijeme prosljedite ekstra hit megapopularnog Massima. Uživajte u ovoj ekstra izvjedbi.

- 16:26 - Komentari (0) - Isprintaj - #

nedjelja, 11.12.2011.

Ljupka Dimitrovska-Godine nisu vazne

Ja zbilja mislim da godine nisu važne. Uživajte dragi moji s jednim od najboljih makedonskih ženskih vokala - Ljupka Dimitrovska.

- 07:23 - Komentari (0) - Isprintaj - #

subota, 24.09.2011.

Garo, Tavitjan Brothers i Nina Badrić - Ne kažuvaj libe dobra noć

target=_blank>

- 14:03 - Komentari (0) - Isprintaj - #

petak, 02.09.2011.

Makedonija - Hrvatska 78:76

Eurobasket 2011

- 07:47 - Komentari (0) - Isprintaj - #

srijeda, 31.08.2011.

TRIBINA: DOWN SYNDROM - IZAZOV RODITELJU, SUPORT ZRELOSTI DRUŠTVA

Poštovane kolegice i kolege,

Na zahtijev roditelja osoba s Down sy., Republike Makedonije,Trisomija 21 u suradnji s domaćinom, Makedonskim naučnim združenjem za autizam, na čijem je čelu predsjednik prof. dr sc. Trajkovski, organizira tribinu pod nazivom: DOWN SYNDROM - IZAZOV RODITELJU, SUPORT ZRELOSTI DRUŠTVA

PROGRAM

Prim.mr.sc Milivoj Kramarić, psihijatar (Zagreb),
TEMA: Skrb o mentalnom zdravlju osoba s intelektualnim teškoćama (IT) u Republici Hrvatskoj

dr Acka Tushevska, specijalizantica iz psihijatrije (Skopje/Zagreb)
TEMA: Postpartalna depresivna stanja kod žena koje su rodile dijete s Down syndrom-om

Prim.dr sci.med. Nikola Simonoski (Ohrid),
TEMA: Kirurška iskustva u ambulantnom radu s osobama s intelektualnim teškoćama

Helena Melovnik Zrinjski, roditelj, izvrš. dir. Trisomije 21 (Zagreb)
TEMA: Moje dijete ima Down sy.

Prof. dr sc. Vladimir Trajkovski, domaćin, predsjednik MNZA
TEMA: Novosti u genetici Down sy.

Iskustva roditelja osoba s Down sy. Republike Makedonije

Predsednik MNZA

- 20:35 - Komentari (0) - Isprintaj - #

nedjelja, 28.08.2011.

Information and Communication Technologies (ICT) for Enhanced Education of Children with Autism Spectrum Disorders

Evdokimos I. Konstantinidis, Andrej Luneski, Christos A. Frantzidis, Maria M. Nikolaidou, Magda Hitoglou-Antoniadou, Panagiotis D. Bamidis

ABSTRACT
Recent developments in the area of information and communication technologies for people with special
needs led to significant changes in the way specialists and educators face the daily impairments posed by
abnormal behaviors. Computer based educative methods have recently been considered as a key element
for educating people with autistic spectrum disorders (ASDs). Latest literature reveals that persons with
autism, especially children, enjoy interacting with computers and consider them as a “safe” environment
due to the lack of expectations and judgments that make social interaction problematic. Virtual
Environments (VEs), usually accompanied by 3D humanoid characters have been proven to play
essential role in special education and social interventions. In addition, emotionally expressive avatars
advance the quality of tutor-learner interaction. Furthermore, unobtrusive wireless sensors often
integrate autistic person’s feedback and reaction. This paper attempts to demonstrate specific artifacts in
a proof of concept fashion with a long term purpose to improve the educational process of people with
ASDs.

KEYWORDS: Computer-aided learning, affective computing, autism, emotions, human-computer
interaction, avatars.